Nausea, heartburn, indigestion, upset stomach, diarrhea. All of these are signs it might be time to reach for that pink bottle in the medicine cabinet, something that — as a brand — Pepto-Bismol has come to bank on. Knowing that, OPEN Forum would suggests it shouldn’t rebrand. But what do you do when your brand can no longer count on its consumers? Here are 10 signs it might be time for your trademark to turn in a new direction — or maybe not.